Detection and Analysis of Myocardial Damage Accompanied with Rotavirus-caused Infantile Diarrhea_West China Medical Journal

Authors：

LI Li , REN Hua , LI Baocun

Pediatric Department, Yan’an University Affiliated Hospital, Yan’an, Shaanxi 716000, P. R. China;

Corresponding author：

Keywords：

轮状病毒; 婴幼儿; 腹泻; 心肌损害; 肌酸磷酸激酶同工酶

DOI：

CNKI: 51-1356/R.20120214.2032.054

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目的　分析轮状病毒性腹泻患儿心肌受损情况和所伴随生化检验指标改变。方法　 2008年7月－2010年7月收治腹泻患儿80例，年龄6～27个月，平均12.9个月。其中有50例为轮状病毒腹泻（A组），30例为非轮状病毒性腹泻（B组）。A组患儿均符合轮状病毒腹泻诊断标准，有心肌损伤的异常指标但达不到心肌炎诊断标准者诊断为心肌损害。B组患儿有水样腹泻，但症状较轻，病程较短，轮状病毒抗原检测阴性。用全自动生化分析仪测定血清谷草转氨酶、乳酸脱氢酶、肌酸磷酸激酶和肌酸磷酸激酶同工酶，免疫亲和层析法测定血清肌钙蛋白值，并进行心电图检查。结果　 A组50例轮状病毒性腹泻患儿中，44例（88.0%）存在心肌损害，其血清谷草转氨酶（74.32 ± 13.77）U/L、肌酸磷酸激酶（52.01 ± 10.37）U/L、肌酸磷酸激酶同工酶（273.43 ± 27.55）U/L均升高，且明显高于B组[（24.98 ± 7.03）、（17.11 ± 6.52）、（151.46 ± 16.52）U/L]，差异有统计学意义(P＜0.05)。两组患儿的乳酸脱氢酶变化差异无统计学意义(P＞0.05)。结论　轮状病毒性腹泻患儿往往伴有心肌损害及相应的血液生化检测指标改变；以肌酸磷酸激酶同工酶作为近期心肌损害的诊断指标更为特异和敏感。

Citation： LI Li,REN Hua,LI Baocun. Detection and Analysis of Myocardial Damage Accompanied with Rotavirus-caused Infantile Diarrhea. West China Medical Journal, 2012, 27(2): 242-244. doi: CNKI: 51-1356/R.20120214.2032.054 Copy

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1. 方肇寅, 齐锦, 杨辉, 等. 我国1998-1999年流行的婴幼儿腹泻轮状病毒分型研究[J]. 病毒学报, 2001, 17(2): 17-23.
2. 全国腹泻病防治研讨会. 轮状病毒肠炎[J]. 中国实用儿科杂志, 1998, 13(6): 381-384.
3. 全国小儿心肌炎、心肌病学术会议. 小儿病毒性心肌炎诊断标准[J]. 中华儿科杂志, 2000, 38(2): 75-76.
4. Das BK, Gentseh JR, Cirello HG, et a1. Characterization of mtavims strains from ilew-bores in New Delhi, India[J]. J Clin Mi-crobiol, 1994, 32(12): 1820-1822.
5. Kaidam I, Shif L, Keren G. Rotavirus encephalopathy evidece of central nervotls system involvement during rotavius infection[J]. Pediatr Infect Dis, 1992, 11(2): 773.
6. Ramani S, Sankaran P, Arumugam R. Comparison of viral load and duration of virus shedding in symptomatic and asymptomatic neonatal rotavirus infections[J]. J Med Virol, 2010, 82(10): 1803-1807.
7. Makis A, Stavrou S, Chaliasos N. Acute febrile neutrophilic dermatosis (Sweet’s syndrome) in a child, associated with a rotavirus infection: a case report[J]. J Med Case Reports, 2010, 4(1): 281.
8. Grimwood K, Lambert SB, Milne RJ. Rotavirus infections and vaccines: burden of illness and potential impact of vaccination[J]. Paediatr Drugs, 2010, 12(4): 235-256.
9. Clark HF, Marcello AE, Lawley D. Unexpectedly high burden of rotavirus gastroenteritis in very young infants[J]. BMC Pediatr, 2010, 10(1): 40.
10. Collins PJ, Martella V, Sleator RD. Detection and characterisation of group A rotavirus in asymptomatic piglets in southern Ireland[J]. Arch Virol, 2010, 155(8): 1247-1259.
11. Patel M, Rench MA, Boom JA. Detection of rotavirus antigenemia in routinely obtained serum specimens to augment surveillance and vaccine effectiveness evaluations[J]. Pediatr Infect Dis J, 2010, 29(9): 836-839.
12. Lloyd MB, Lloyd JC, Gesteland PH. Rotavirus gastroenteritis and seizures in young children[J]. Pediatr Neurol, 2010, 42(6): 404-408.
13. Takanashi J, Miyamoto T, Ando N. Clinical and radiological features of rotavirus cerebellitis[J]. AJNR Am J Neuroradiol, 2010, 31(9): 1591-1595.
14. Ghosh S, Alam MM, Ahmed MU. Complete genome constellation of a caprine group A rotavirus strain reveals common evolution with ruminant and human rotavirus strains[J]. J Gen Virol, 2010, 91(Pt 9): 2367-2373.

West China Medical Journal

Detection and Analysis of Myocardial Damage Accompanied with Rotavirus-caused Infantile Diarrhea

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